Volume 2, Issue 5, October 2017, Page: 47-50
Toxicity Effect of Launaea taraxacifolia Aqueous Extract on Vital Organs of Albino Rat
Florence Ifechukwude Aboderin, Department of Heamatology and Immunology, Obafemi Awolowo University, Ile-Ife, Nigeria
Joshua Seun Olajide, Centre for Distance Learning, Obafemi Awolowo University, Ile-Ife, Nigeria
Adekunle Abiodun Adesiyan, Department of Chemical Pathology, Ladoke Akintola University of Technology, Ogbomoso, Nigeria
Received: Sep. 4, 2017;       Accepted: Sep. 21, 2017;       Published: Oct. 23, 2017
DOI: 10.11648/j.ijbbmb.20170205.12      View  1224      Downloads  89
Abstract
Launaea taraxacifolia (Efo yanrin) aqueous extract was orally administered to albino rats with view to investigating the haematological, biochemical and histological difference on body organs. Fifteen (15) albino rats divided into five groups each of three rats were used. Group I was the control while groups II III, IV, and V were dosed with 500mg/kg, 1000mg/kg, 2000mg/kg and 3000mg/kg respectively. Rats treated with different doses of aqueous extracts had increase packed cell volume with a significant increase of 43% in groups II and V alongside with Haemoglobin of 14.3mg/dl increase compared with the control. Moreover, the differential leucocyte counts revealed moderate increase in the lymphocytes count of groups II and V when compared with normal value. The aqueous extract of L. taraxacifolia is safe and has immunostimulatory effect. However, the effect of the extract on the liver of rats has varying degrees of lesions ranging from mild to severe diffuse degeneration of hepatocytes with periportal cellular infiltration. There was presence of multiple foci of caseous necrosis of the hepatic cells. Animals to which aqueous extract was administered at graded doses showed presence of eosinophilic cast in degenerated tubules with cellular infiltration in the renal interstitium. The histological result showed that the aqueous extract of L. taraxacifolia, could be toxic to the liver and kidney and caution should therefore be exercised in its use for medicinal purpose.
Keywords
Toxicity, Launaea taraxacifolia, Extract, Herbal, Rat
To cite this article
Florence Ifechukwude Aboderin, Joshua Seun Olajide, Adekunle Abiodun Adesiyan, Toxicity Effect of Launaea taraxacifolia Aqueous Extract on Vital Organs of Albino Rat, International Journal of Biochemistry, Biophysics & Molecular Biology. Vol. 2, No. 5, 2017, pp. 47-50. doi: 10.11648/j.ijbbmb.20170205.12
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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